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AP: 44810f18-60a0-4d08-96e4-2c1d4587a47b
Actress Jennifer Garner, left, actor Matthew McConaughey, director Jean-Marc Vallee and actor Jared Leto at the premiere of "Dallas Buyers Club" on day 3 of the 2013 Toronto International Film Festival at The Princess of Wales Theatre on Saturday, Sept. 7, 2013 in Toronto. (Photo by Evan Agostini/Invision/AP)
Could a body transformation equal an Oscar nomination, or better yet, a win?

For some actors, memorizing lines, learning a new accent or chopping off their hair, can be all the preparation necessary for a film role. For others, the commitment may require a full-on body transformation, whether that means slimming down or bulking up.

But can the Hollywood equivalent of yo-yo dieting be safe for a layperson? Probably not, and trying it at home without medical supervision could lead to the emergency room (so I would certainly NOT recommend it!).

In Hollywood however, it could lead to an Oscar.

The film "Dallas Buyers Club" made its premier at the Toronto Film Festival over the weekend and many people have already predicted Oscar potential for Matthew McConaughey and Jared Leto, who lost approximately 80 combined pounds for their roles.

In April, McConaughey admitted to "hardcore" dieting to lose the weight, causing him to become irritable but eventually leading to what he described as a "spiritual and mental cleanse."

Leto revealed that he pretty much "stopped eating" to lose more than 30 pounds, and it's not the first time the actor-singer physically committed to his character. He gained 67 pounds -- back in 2007 -- for the role of John Lennon's assassin, Mark David Chapman, in "Chapter 27."

See below at how far other actors went to earn their golden statuette, or at least a nomination.

Mini Salas, Host

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