Schofield, who injured his ankle during last Sunday's 31-17 loss to the Green Bay Packers, finishes the season with 34 total tackles and four sacks.
To take Schofield's place on the roster, the team has re-signed defensive end Ronald Talley. The 6-foot-3, 286-pound Talley played in six games with the Cardinals in 2011, registering two total tackles. He was cut in the preseason.
In another roster move, Arizona also re-signed cornerback Greg McCoy to the practice squad to take the spot of cornerback Crezdon Butler, who was signed by the Buffalo Bills off of the Cardinals practice squad.