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Arizona Cardinals’ Week 1 history

September 9, 2012 - University of Phoenix Stadium Cardinals 20, Seahawks 16 Replacing injured starter John Skelton, Kevin Kolb comes off the bench to lead Arizona's game-winning touchdown drive in the fourth quarter. September 11, 2011 - University of Phoenix Stadium Cardinals 28, Panthers 21 Despite a record-setting day from rookie Cam Newton, Kevin Kolb wins his Cardinals debut with two long touchdown passes to Jeff King and Early Doucet. September 12, 2010 - Edward Jones Dome Cardinals 17, Rams 13 Kerry Rhodes' late-game interception proved to be the difference as Arizona survived a defensive slugfest. September 7, 2008 - Monster Park Cardinals 23, 49ers 13 Arizona's defense forced five turnovers and battered San Francisco starting quarterback J.T. O'Sullivan. September 10, 2007 - Monster Park 49ers 20, Cardinals 17 The bright lights of Monday Night Football were unkind to Matt Leinart, who threw two interceptions in a three-point loss. September 10, 2006 - University of Phoenix Stadium Cardinals 34, 49ers 27 Kurt Warner threw for 301 yards and three touchdowns, as Arizona escaped an offensive shootout with a seven-point win. September 11, 2005 - Giants Stadium Giants 42, Cardinals 19 Tiki Barber's 21-yard touchdown run keyed a 35-point second half for Big Blue, who won going away. September 12, 2004 - Edward Jones Dome Rams 17, Cardinals 10 Emmitt Smith's 11-yard touchdown run wasn't enough as St. Louis rallied with a late scoring drive in the fourth quarter. September 8, 2002 - FedEx Field Redskins 31, Cardinals 23 Stephen Davis' third quarter touchdown put Washington up for good as Arizona's defense allowed 449 total yards. September 23, 2001 - Sun Devil Stadium Broncos 38, Cardinals 21 Arizona had a rare Week 1 bye but the added rest wasn't helpful going into their Week 2 matchup. Olandis Gary rushed for 90 yards and a touchdown in the 17-point romp. September 3, 2000 - Giants Stadium Giants 21, Cardinals 16 New York scored three rushing touchdowns on the afternoon capped off by Ron Dayne's eventual game-winning score in the fourth quarter.