Arizona Cardinals WR John Brown, CB Brandon Williams active vs. Seattle

Dec 24, 2016, 1:19 PM
Arizona Cardinals wide receiver John Brown (12) celebrates his touchdown with tight end Jermaine Gr...

Arizona Cardinals wide receiver John Brown (12) celebrates his touchdown with tight end Jermaine Gresham (84) during the second half of an NFL football game against the New Orleans Saints, Sunday, Dec. 18, 2016, in Glendale, Ariz. (AP Photo/Rick Scuteri)

(AP Photo/Rick Scuteri)

With safety Tyrann Mathieu placed on injured reserve earlier, the Arizona Cardinals had but two question marks heading into their Week 16 visit to Seattle: wide receiver John Brown and cornerback Brandon Williams.

The answer: both will play.

Brown, as he has for some time now, is dealing with hamstring tightness as a result of having the sickle-cell trait. He was limited all week in practice.

Williams missed practice Thursday and was limited Friday because of a back issue. He’s expected to make his first start since Sept. 18 against Tampa Bay and third overall this season.

The Cardinals’ seven inactives are wide receiver Marquis Bundy, cornerback Marcus Cooper, quarterback Zac Dysert, tackle D.J. Humphries, plus defensive tackles Olsen Pierre, Ed Stinson and Xavier Williams.

Cooper (back/calf) and Humphries (concussion) had already been ruled out. It’s the second straight game Humphries will miss.

Cornerback Harlan Miller and safety Trevon Hartfield, promoted this week from the practice squad, are active.

For the Seahawks, running back C.J. Prosise (shoulder) is out due to injury.

The others not in uniform for Seattle are defensive tackle John Jenkins, running back J.D. McKissic, linebacker Ronald Powell, safety Tyvis Powell, tackle Bradley Sowell, the one-time Cardinal, and tight end Nick Vannett.

Defensive tackle Michael Bennett is good to go despite a neck problem that kept him off the practice field on Wednesday.

The Cardinals have won in two of their last three trips to the Pacific Northwest, including a year ago, a 39-32 victory.

“Protecting the football, running the football, and we’ve made some big plays — gotten the lead or hung right there,” head coach Bruce Arians said, referring to the keys to winning at CenturyLink Field. “We had the big lead last year and lost it. That’s what made it so special about come back, especially at that place. That’s usually the key.”

Follow Craig Grialou on Twitter

Arizona Cardinals

Arizona Cardinals defensive tackle Corey Peters (98) walks out before an NFL game between the Arizo...
Nikash Nath

PFF’s Doug Kyed advises Arizona Cardinals to bring back DL Corey Peters

With the Cardinals' current roster construction, PFF's Doug Kyed believes Arizona should bring DL Corey Peters back once more in 2022.
1 day ago
Ohio State Buckeyes offensive lineman Paris Johnson Jr. (77) protects his quarterback during the fi...
Sam Graveline

Cardinals take OT Paris Johnson Jr. in ESPN 2023 NFL mock draft

ESPN's Matt Miller thinks the Cardinals will beef up the offensive line in his first 2023 mock by selecting Ohio State OT Paris Johnson Jr.
3 days ago
Arizona Cardinals coach Kliff Kingsbury, right, and Byron Murphy Jr. (7) celebrate after an NFL foo...
Wills Rice’s Patra ranks Cardinals’ cornerbacks among weakest rooms in league

The Cardinals enter training camp with a few question marks personnel-wise on the defensive side of the ball, especially at cornerback.
4 days ago
Nick Scott #33 of the Los Angeles Rams tackles Zach Ertz #86 of the Arizona Cardinals after a recep...
Sam Graveline

PFF: Tight end shaping up to be biggest position battle for Arizona Cardinals

The Arizona Cardinals head into training camp expecting to have healthy competition at a handful of positions, including at tight end.
5 days ago
Kyler Murray #1 of the Arizona Cardinals celebrates with fans after beating the Houston Texans 31-5...
Arizona Sports

Cardinals Corner: The timeframe of Kyler Murray’s contract extension

We haven't heard much lately when it comes down to Cardinals QB Kyler Murray and a contract extension. When will a new deal get done?
5 days ago
Markus Golden #44 of the Arizona Cardinals reacts to a defensive play during the first half against...
Nikash Nath

Cardinals LB Markus Golden among players with best team-friendly deals

Arizona Cardinals LB Markus Golden's contract cracked PFF analyst Brad Spielberger's top team-friendly deals ranking.
5 days ago
Arizona Cardinals WR John Brown, CB Brandon Williams active vs. Seattle