Midway through the second quarter of Arizona's game against the Falcons, the former fifth-round pick out of Fordham was replaced in favor of rookie quarterback Ryan Lindley.
Despite three first quarter interceptions by the Cardinals defense, Skelton began the game just 2-for-7 for six yards.
Skelton began the season as the team's starter before suffering a right ankle injury in the team's 20-16 win over the Seattle Seahawks. After Kevin Kolb sustained a rib injury in the fourth quarter of Arizona's Week 6 loss to the Buffalo Bills, Skelton once again took over the starting duties.
In his last three starts, Skelton is 0-3.
Lindley, who was selected in the sixth round by the Cardinals in last April's draft, came into Sunday's game with no career pass attempts.